RAF Typhoon jets have joined forces with French warplanes in a coordinated attack against an underground arms cache in Syria employed by the Daesh militant organization, according to the UK's MoD.
The site, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was located in hills just north of the ancient city of Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a series of access tunnels down to the site... preliminary assessments are that the target was engaged successfully," officials stated.
There was no indication of any civilian impact in the strike on Saturday evening and all the aircraft returned safely, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
IS - referred to as ISIS - established jihadist rule over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This strike underscores British leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any re-emergence of IS and their harmful and extremist ideologies in the area," the British Defence Secretary the minister said.
British military aircraft have conducted overwatch operations over Syrian airspace to "prevent any attempted comeback" of Islamic State following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank the personnel of our armed forces involved in this strike for their professionalism and their valour," he added. "They were among a great many UK service members deployed over the holidays. This operation, to remove terrorist threats who threaten our security, demonstrates how UK forces are always on standby, all year round, ensuring Britain's security domestically and strong abroad."
In December, the American forces conducted what it described as a "massive strike" targeting IS targets in Syria, subsequent to an ambush resulted in the deaths of two US troops and a local interpreter in the Palmyra area.
The UN says IS still maintains between 5,000 and 7,000 militants in both countries.